β-Caryophyllene as an Anxiolytic

β-Caryophyllene is a sesquiterpene found naturally in plants. β-Caryophyllene is considered a dietary cannabinoid because it can activate the CB2 receptor and cause metabolic changes to brain chemistry. β-Caryophyllene has been researched for its ability to affect anxiety in animal models of mood disorders. For example, in one study, researchers administered β-caryophyllene to mice and measured the behavioural changes that occurred when stressful situations were created for the animals. The results of the study showed that a number of behavioural changes that could be related to anxiousness were favourably altered by the β-caryophyllene including the amount of time spent in the open (relating to anxious behaviour) and reductions in burying and digging behaviour (related to compulsive behaviour, a form of anxiety). Administration of a CB2 receptor agonist attenuated the beneficial effects of the β-caryophyllene suggesting that it was likely having its effects through the CB2 cannabinoid receptor. 

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Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M. and Ojha, S. 2014. β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiology & behavior. 135: 119-124

About Robert Barrington

Robert Barrington is a writer, nutritionist, lecturer and philosopher.
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