Category Archives: Homocysteine

Folic Acid and Homocysteine

Posted on May 25, 2023 by Robert Barrington

Homocystien is a product of methionine metabolism. Homocysteine has been shown to have detrimental effects on cells and tissues if levels rise. Under normal circumstances homocysteine is converted to other substances that are benign in their effects and so homocysteine … Continue reading →

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Folic Acid Does Elevate Plasma Folate Levels

Posted on July 5, 2018 by Robert Barrington

Folate is an essential dietary component that belongs to the B vitamin group. Folate is found in most plant material, but certain grains and green leafy vegetables can be a good source. Folic acid has a similar structure to folate, … Continue reading →

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Whole Grains: Cardioprotective

Posted on September 15, 2016 by Robert Barrington

Whole grains are defined as food products derived from cereal grains that retain their original bran, germ and endosperm levels. Refined grains have most of the bran and germ layers removed to leave just the starchy endosperm. As the bran … Continue reading →

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Hydrogen Sulphide and Vitamin B6

Posted on May 9, 2016 by Robert Barrington

A number of gases are known to function as signal molecules in animals. The role for nitric oxide as a signal molecule in endothelial cell is well established, and in this role it is able to allow the relaxation of … Continue reading →

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Homocysteine, Cysteine and Plasma Proteins

Posted on August 7, 2015 by Robert Barrington

Homocysteine is a product of methionine metabolism. Evidence suggests that high levels of plasma homocysteine are a risk factor for cardiovascular disease. As methionine metabolism proceeds, homocysteine is produced and this homocysteine is then converted to cysteine or back to … Continue reading →

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Seven Reasons why Cholesterol Testing is Pointless

Posted on July 4, 2015 by Robert Barrington

Cholesterol testing is big business, which perhaps explains why it is so widespread. Certainly the actual point of testing the blood cholesterol of large numbers of the population has little benefit and is little to do with science. Cholesterol testing … Continue reading →

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Folic Acid Deficiency: The Cardiovascular Disease Link

Posted on March 5, 2015 by Robert Barrington

Homocysteine is a product of cellular methionine metabolism. Evidence suggests that high levels of plasma homocysteine are a risk factor for cardiovascular disease. Homocysteine may interfere with endothelial physiology through inhibition of nitric oxide synthesis, inducing endothelial dysfunction possibly via … Continue reading →

Posted in Cobalamin, Endothelial Dysfunction, Folate, Homocysteine, Nitric Oxide, Oxidative Stress, Pyridoxine, Vitamin B | Comments Off on Folic Acid Deficiency: The Cardiovascular Disease Link

B Vitamin Status of Hypercholesterolaemic Men

Posted on March 2, 2015 by Robert Barrington

Elevated levels of plasma homocysteine are an independent risk factor for cardiovascular disease because homocysteine can cause damage to the endothelial linings of arteries. Homocysteine in humans can be metabolised to a number of different compounds and these metabolic steps … Continue reading →

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SAM: Associated With Adiposity

Posted on December 26, 2014 by Robert Barrington

S-adenosylmethionine (SAM) is an intermediate high energy compound of the methionine to homocysteine pathway. Methionine is an essential amino acid in human nutrition, and is derived mainly from animal protein in the diet of Westerners. Methionine is converted to SAM, … Continue reading →

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The Betaine Choline Link

Posted on November 16, 2014 by Robert Barrington

Betaine and choline are closely related compounds from a structural and functional perspective. Betaine is also called trimethylglycine and choline is also called tetramethylglycine. Both compounds function as methyl donors, and when choline donates a methyl group it becomes betaine. … Continue reading →

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