Category Archives: Leptin

Exercise Induced Energy Deficits Causes Compensatory Eating

Posted on October 31, 2017 by Robert Barrington

The current mainstream accepted method for causing weight loss is to produce an energy deficit in the individual. This involves increasing energy expenditure or decreasing energy intake such that the total energy input is lower than the total energy output. … Continue reading →

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The Role of the Hypothalamus in Weight Gain

Posted on January 23, 2017 by Robert Barrington

The body possesses a complex feedback mechanisms to ensure adequate energy intake. This feedback mechanisms is located mainly in the hypothalamus and involves neuronal and hormonal mechanisms. Evidence is accumulating that it is a dysfunction in this system that is … Continue reading →

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The Homeostasis of Weight Control

Posted on July 26, 2016 by Robert Barrington

The traditional model of body weight loss considers the only two factors relevant to weight loss to be energy consumed and exercise performed. In this model, energy balance is an equilibrium between these factors. Part of this assumption considers energy … Continue reading →

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Leptin and Insulin

Posted on May 2, 2016 by Robert Barrington

Insulin resistance that is thought to be responsible for many of the metabolic changes that occur with the metabolic syndrome. In particular, insulin resistance is likely a primary driver of body fat accumulation. For example, insulin resistance has been shown … Continue reading →

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More On Leptin Resistance

Posted on January 6, 2016 by Robert Barrington

Leptin is a peptide hormone that is produced in adipocytes. The circulating levels of leptin are proportional to the amount of body fat. Circulating leptin levels therefore increase in obese individuals, as blood leptin levels rise concomitantly with adiposity. Leptin … Continue reading →

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Fructose and Leptin

Posted on December 11, 2015 by Robert Barrington

Evidence suggests that animals fed high fructose diet have increases in adiposity, body weight and energy intake. There are now many such studies in the nutritional literature involving a wide range of animals, but centred mainly on rodents, particularly rats. … Continue reading →

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Postprandial Effects: Glucose Versus Fructose

Posted on November 22, 2015 by Robert Barrington
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The Leptin Story

Posted on March 14, 2015 by Robert Barrington

Leptin is a peptide hormone that was discovered in 1994 by a Scientist called Friedman. Fat cells produce leptin and this signal is used in a feedback loop to allow the maintenance of correct body weight. Mice missing the leptin … Continue reading →

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Obesity As A Disease Of Starvation

Posted on January 15, 2015 by Robert Barrington

Like many biological phenomenon, feeding behaviour is reliant on a negative feedback loop. This loop involves the detection of food in the gut and nutrients in the blood and a subsequent neuronal and hormonal response that corrects behaviour. A loop … Continue reading →

Posted in Insulin, Insulin Resistance, Leptin, Leptin Resistance, Micronutrients, Obesity, Protein, Trace Minerals, Traditional Diets, Western Diet | Comments Off on Obesity As A Disease Of Starvation

Energy Restrictive Diets And Muscle Function

Posted on August 27, 2014 by Robert Barrington

Energy restrictive diets are not effective at causing long term sustainable fat loss in the majority of individuals with obesity. This is because obesity is a disease caused not by eating too much food, but by eating the wrong types … Continue reading →

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