Category Archives: Linoleic Acid

Does Nutrition Affect Telomere Length?

Posted on April 28, 2012 by Robert Barrington

Telomeres are structures on chromosomes that protect against chromosomal fusion during mitotic division. However, through normal division the telomere undergoes erosion which may ultimately trigger programmed cell death. Although the telomeres naturally shorten with age, but this process is though … Continue reading →

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Essential Fatty Acids in Early Development

Posted on April 24, 2012 by Robert Barrington

The two essential fatty acids (EFA), linoleic acid (LA, C18:2 (n-6)) and α-linolenic acid (ALA, C18:3 (n-3)), are required in the diet because humans are unable to synthesise them de novo. A series of elongation and desaturation reactions creates a … Continue reading →

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Fish Oil and Insulin Resistance (in Rats)

Posted on April 16, 2012 by Robert Barrington

Insulin resistance is a metabolic abnormality that is thought to lead to obesity, abdominal weight gain, cardiovascular disease and type 2 diabetes. The cause of insulin resistance is unknown, but evidence suggests that fatty acids play a role in its … Continue reading →

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Diet and Disease

Posted on February 11, 2012 by Robert Barrington

The impact of diet on long-term health is evident from the literature, with many studies highlighting the benefits of improved diet quality on reductions in mortality and morbidity. Much of the damage from a poor quality diet is caused by … Continue reading →

Posted in Linoleic Acid, Polyunsaturated Fatty Acids, Tocopherols, Tocotrienols, Vitamin E, Whole Grains | Comments Off on Diet and Disease

Polyunsaturated Fatty Acids and PPAR

Posted on January 24, 2012 by Robert Barrington

The peroxisome proliferator-activated receptor (PPAR) family are ligand-activated nuclear transcription factors involved in the regulation of lipid metabolism through gene expression of peroxisome number. It is thought that the PPAR are activated by C18 to C22 n-3 and n-6 fatty … Continue reading →

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Important Long Chain Fatty Acids

Posted on January 8, 2012 by Robert Barrington

There are a number of long chain fatty acids that are important to human health (figure 1). The essential fatty acids alpha-linolenic (ALA, C18:3 (n-3)) acid and linoleic acid (LA, C18:2 (n-6)) cannot be synthesised by humans but are vital … Continue reading →

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Fatty Acid Profiles During Pregnancy

Posted on December 26, 2011 by Robert Barrington

Evidence is growing that the long-chain fatty acids from fish are beneficial to the health. Docosahexanoic acid (DHA, C22:6 (n-3)) and eicosapentanoic acid (EPA, C20:5 (n-3)) have been shown to play an important role in preventing inflammation caused by the … Continue reading →

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Essential Fatty Acids in Skin

Posted on November 18, 2011 by Robert Barrington

Skin conditions are associated with n-6 fatty acids but generally not with n-3 fatty acid. The result of n-6 deficiency is increased inflammation, which includes heat, pain, redness, swelling, and loss of function. This can cause weeping, increased proliferation of … Continue reading →

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Conjugated Linoleic Acid and Myocardial Infarction

Posted on September 3, 2011 by Robert Barrington

Conjugated linoleic acid (CLA) is a group of isomers of the essential fatty acid fatty acid linoleic acid that are formed almost exclusively in the stomachs of ruminant animals (e.g. cattle, sheep, goats and antelopes). The cis-9, trans-11 form of … Continue reading →

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Fatty Acids, Eicosanoids and Arachidonic Acid

Posted on August 17, 2011 by Robert Barrington

Alpha linolenic acid (ALA) and linoleic acid (LA) are polyunsaturated fatty acids (PUFA) of the omega 3 and 6 family respectively, and are both essential to health. These fatty acids have a number of important function in humans, and deficiency … Continue reading →

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