Category Archives: Syndrome X

Physical Activity and Body Fat

Posted on May 25, 2012 by Robert Barrington

The association between physical activity and body fat is well established. For example, a prospective study1 that followed 84,511 men and 203,987 women for 5.1 years categorised the subjects into groups based on their physical activity levels. Inactive, moderately inactive, … Continue reading →

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More on Choline, Betaine and Homocysteine

Posted on March 29, 2012 by Robert Barrington

Raised plasma levels of the amino acid homocysteine are known to damage tissues and are a risk factor for dementia, cardiovascular disease and bone fractures. Homocysteine is synthesised in humans from the essential amino acid methionine and under normal physiological … Continue reading →

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Fructose and Fatty Acid Synthesis

Posted on March 28, 2012 by Robert Barrington

Consumption of unrefined whole grains are associated with beneficial health effects, whereas refined simple sugars are associated with disease. In particular, high intakes of fructose are suspected of playing a role in the development of obesity, metabolic syndrome, diabetes and … Continue reading →

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More on Insulin Resistance

Posted on March 24, 2012 by Robert Barrington

Insulin resistance is a condition where the sensitivity of the insulin receptor is reduced and the cellular responses caused by an increase in blood sugar become abnormally blunted. Insulin resistance is associated with diabetes, cardiovascular disease, hypertension and metabolic syndrome … Continue reading →

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The Metabolic Syndrome and Exercise

Posted on March 16, 2012 by Robert Barrington

Metabolic syndrome is a disorder characterised by central adiposity, insulin resistance and detrimental blood lipid changes, which increases the risk of cardiovascular disease and type 2 diabetes. The detrimental physiological changes that accompany metabolic syndrome may be the underlying causative … Continue reading →

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More Evidence for Mineral Deficiencies in Overweight Individuals

Posted on February 12, 2012 by Robert Barrington

Research suggests that obesity is caused by complex metabolic changes which result in insulin resistance, abdominal fat accumulation and lipoprotein changes. In addition, inflammation and oxidative stress appear to be elevated in obese individuals, possibly as a result of increased … Continue reading →

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More on Vitamin D and Diabetes

Posted on February 9, 2012 by Robert Barrington

Vitamin D is a hormone that research has shown to have been underestimated with regard to its importance in human health. The traditional view of vitamin D is that deficiency leads to the bone diseases osteomalacia in adults and rickets … Continue reading →

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More on Exercise and Weight Change

Posted on December 30, 2011 by Robert Barrington

The mainstream medical viewpoint on weight gain is that it is caused by a positive energy balance, as a direct result of a low energy expenditure coupled to a high energy intake. However, despite the persistence of this view, research … Continue reading →

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More on Adiponectin

Posted on December 24, 2011 by Robert Barrington

The cause of obesity is not fully understood, but it is becoming clear that metabolic dysfunction leading to insulin resistance is a contributory factor. Obesity is characterised by chronic systemic inflammation, because as white adipose tissue accumulates, pro-inflammatory cytokines are … Continue reading →

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Adiponectin, Lifestyle and Diet

Posted on December 23, 2011 by Robert Barrington

Weight gain and obesity are increasingly being associated with inflammation, hormonal changes and metabolic dysfunction. Excess energy causes the accumulation of white adipose tissue, and this leads to an influx of macrophages to adipoctyes. This is followed by a release … Continue reading →

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