Chromium picolinate is a supplemental form of dietary chromium with high bioavailability. The most well known role for dietary chromium in human nutrition is as a factor required for the correct function of the insulin system. As insulin has so many cellular functions, this gives chromium wide ranging physiological effects in humans. On possible role for chromium is as an antidepressant. Certainly evidence is accumulating that a chromium deficiency in animals and humans may lead to mood disorders. For example, in one study researchers administered chromium picolinate to rats at 8 micrograms per mL of drinking water. The administration of chromium significantly lowered the blood glucose levels of the rats. In addition, a significant antidepressant effect for the chromium was shown in the rats. The authors concluded that the effects of chromium may be attributed to changes in the serotonergic system of the brain. This may be controlled centrally through changes in blood sugar regulation.
Chromium facilitates the entry of glucose to cells, thus lowering blood glucose levels. This may have profound effects on neurotransmitter production in the brain, as many pathways in the brain are regulated by insulin and energy levels.
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