The cause of depressed mood is considered to be stress. External stressors are able to cause changes to the delicate tissues of the brain that include the development of inflammation. This inflammation then leads to oxidative stress via the generation of free radicals, and this causes detrimental changes to brain chemistry. Targeting inflammation is therefore a major route to treating mood disorders therapeutically. The benefits of reducing inflammation in the treatment of mood has been investigated in spinal cord injury patients with depression. The subjects received either 12 weeks of an anti-inflammatory diet, or 12 weeks of a control diet, and during this period their mood and their levels of inflammation measured. The results of the study showed that the anti-inflammatory diet was significantly effective at reducing inflammation in the subjects and this was accompanied by improvements in mood and improvements in the levels of neuroactive compounds relating to serotonin synthesis in the blood.
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