Studies consistently show that male animals respond to D-aspartic acid supplementation with increased synthesis of testosterone. However, the human results from studies have been more inconsistent, and this likely relates to either methodological problems with controlling human diets and lifestyles, or species differences in the metabolism and use of D-aspartic acid as a nutrient. For example in resistance trained men, studies have noted that hormonal levels are not significantly altered with supplementation, although effects are seen more consistently in sedentary men. The question therefore arises as to whether men with a resistance training background require more D-aspartic acid in order to elevate testosterone levels? However in answer to this question, when one study used high doses of D-aspartic acid on resistance trained men at the 6 gram per day dosage, free and total testosterone levels were reduced. This suggests that the metabolism and pharmacology of D-aspartic acid are complex and it is not simply a case of using the supplement to see beneficial effects. Some care must therefore be taken to find the desirable dose and to avoid unnecessary detrimental effects by using doses that are either too large, too small, or directed towards the wrong individuals in the wrong circumstances.
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Melville, G. W., Siegler, J. C. and Marshall, P. W. 2015. Three and six grams supplementation of d-aspartic acid in resistance trained men. Journal of the International Society of Sports Nutrition. 12(1): 15
