The human detoxification pathways are complex. However, a simplistic model states that there are two main detoxification enzyme systems in the liver. These are called the phase 1 and phase 2 enzyme systems. Cruciferous vegetables of the Brassica family can be beneficial because they modulate these enzyme systems to prevent the over production of carcinogenic compounds. In this regard, the phase 1 enzyme system is an activating step in detoxification, and the products can be highly damaging to cells. The phase 2 enzyme system takes these highly toxic compounds and creates less toxic and water soluble forms to be excreted. The glucosinolate chemicals in cruciferous vegetables inhibit phase 1 enzymes but activate phase 2 enzymes. This limits the production of the toxic phase 1 metabolites to a shorter half life by decreasing production and increasing elimination. This has the overall effect of protecting cells and tissues. Cruciferous vegetables with this effect include broccoli, cabbage, cauliflower, watercress and sprouts.
Eat Well, Stay Healthy, Protect Yourself
RdB
