Coleus forskolin is a plant that grows in Nelap, India and Thailand. The plant has a number of medicinal effects and these likely relate to the presence of a diterpene molecule within the plant tissues called forskolin. Forskolin has been shown to stimulate the enzyme cyclic adenosine monophosphate (cAMP), which is a key regulator of cell function. Cyclic AMP may have different functions in different cell types, and this explains the wide number of uses of forskolin. In terms of weight loss, cyclic AMP is able to trigger the breakdown of triglycerides from adipose tissue, and can also upregulate fatty acid oxidation. Therefore forskolin may have weight loss effects by regulating these two key cellular functions, thus increasing the amount of fat oxidised for energy. Studies on humans show that forskolin has relevant and measurable clinical effects and can significantly decrease body fat in overweight humans subjects. Studies also suggest that forskolin is safe and effective for long term use, and in fact taking it over the long term may elicit the best results in terms of improvements in body composition and decreases in body fat. Health effects from reduced body fat, particularly from the abdomen, include reductions in blood pressure and this may decrease the risk of cardiovascular disease.
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