Glutathione as a Chelator of Heavy Metals

Glutathione is the most common low molecular weight sulfhydryl-containing compound in human and animal cells and is present in all cells in low amounts. Evidence suggests that glutathione is able to bind to heavy metals, particularly mercury and this aids elimination of the metal and reduces the damage to the cells. As mercury has a high affinity of sulfhydryl (thiol) groups) this explains the ability of glutathione to eliminate mercury. Studies show that levels of reduced glutathione decrease on exposure of the cells to mercury, suggesting that the glutathione is being used up as mercury enters the cell. Optimising cellular glutathione levels is therefore paramount in protecting cells from mercury poisoning. One way to achieve this is to consume a diet high in antioxidants, as this spares the glutathione and has been shown to increase cellular levels. As some of the damage of mercury stems from its ability to generate free radicals, the antioxidant effects of glutathione are also beneficial in this regard. 

Eat Well, Stay Healthy, protect Yourself

RdB

Patrick, L. 2002. Patrick L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Alternative Medicine Review. 7(6): 456-471

About Robert Barrington

Robert Barrington is a writer, nutritionist, lecturer and philosopher.
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