Glycine has been used to treat schizophrenia effectively as oral glycine is able to improve glutamate neurotransmission in the brain, suggesting that glycine is able to enter the brain across the blood brain barrier, and here have an effect on brain neurochemistry. In this regard, glycine appears able to act as an agonist to a number of receptors that are sensitive to the N-methyl D-aspartate neurotransmitter. Another interesting aspect of glycine administration is that the glycine may increase the synthesis of creatine in brain tissue, something which may improve the energy content of the brain, and something that may improve brain function. In healthy individuals, brain levels of glycine are raised significantly following supplementation. Taking glycine in water as a supplement therefore appears to be an effective way of delivering glycine to the brain. As glycine has a number of functions in physiology, this may suggest that glycine could potentially have therapeutic uses simply through oral routes of administrations.
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