Luteinizing hormone is an important step in the synthesis of testosterone. Luteinizing hormone is produced by the anterior pituitary in response to signals from the hypothalamus in the brain. Luteinizing hormone is important because it enters the circulation and stimulates receptors on the testes to initiate the synthesis of testosterone. Optimising luteinizing hormone is therefore of importance to athletes and those that wish to maintain optimal testosterone levels. Luteinizing hormone is released in a pulsatile fashion from the anterior pituitary and it is likely that norepinephrine attaches to alpha adrenergic receptors to induce the synthesis of prostaglandin E2. The prostaglandin E2 in turn causes the release of luteinizing hormone releasing hormone, which then travels from the hypothalamus to the posterior pituitary to cause the release of luteinizing hormone. Evidence suggests that nitric oxide facilitates the release of luteinizing hormone releasing hormone from the hypothalamus.
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