Evidence suggests that serotonin deficiency is a causative factor in the development of depressive symptoms. There is also evidence that deficiencies of the catecholamines including dopamine, noradrenaline and adrenaline may also be involved in the development of mood disorders. The enzyme aromatic amino acid decarboxylase is required for the synthesis of these neurotransmitters and the enzyme in turn is dependent on the presence of pyridoxal phosphate (vitamin B6). Deficiencies of vitamin B6 may therefore interfere with the metabolism of the key neurotransmitters needed for the correct function of mood. Supplemental vitamin B6 may increase flux through the aromatic amino acid decarboxylase enzyme and therefore may be an effective treatment for certain forms of depression. Therefore because a vitamin B6 deficiency may increase the risk of depressive symptoms, it is important to maintain adequate intakes of vitamin B6 from diet or supplements to maintain proper brain function.
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