Phosphatidylserine is a normal component of phospholipids in cell membranes. Nutritionally a good source of phosphatidylserine is soya, and many phosphatidylserine supplements are derived from soya. Evidence suggests that phosphatidylserine is able to reduce serum cortisol levels in humans and this may make it a useful supplement to reduce the damaging effect of stress. In one study, 10 healthy male subjects were administered 600 mg of phosphatidylserine for 10 days. The subjects were then exposed to experimental stress in the form of exercise. The results of the study showed that compared to the placebo, the phosphatidylserine was significantly effective at reducing serum cortisol levels in the subjects and this increased the mean testosterone to cortisol ratio. Phosphatidylserine may therefore be an effective supplement to reduce circulating levels of cortisol following exercise and this may translate into a more favourable hormone profile. It is possible that this improved hormone profile may increase mood and well being.
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