Neurodegeneration is can cause damage to the function of the brain. Neurodegeneration is usually associated with diseases such as Alzherimer’s and Parkinson’s disease. However, neurodegeneration can also occur as a result of chronic stress, and in such cases it is often associated with mood disorders, particularly if it is present in the hippocampal region of the brain. Polyphenols are protective of mood disorders because they can slow or reverse neurodegenerative processes. Their protective effects come from the ability of polyphenols to regulate cell function. Mangiferin and morin are two polyphenols that are present in Mangifera indica L (Mango) and Morus alba (white mulberry), respectively. Studies show that mangiferin and morin are able to protect neurones from degeneration and death, through alterations in cell signalling. This may relate to their antioxidant effect which can alter cell signal pathways. This may explain the mood enhancing effects of other polyphenols.
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