Fat free mass is inversely associated with mortality. This relates in part to the fact that as people age muscle mass naturally decreases, which is in part caused by the natural reduction in hormones including growth hormone, testosterone and insulin like growth factor, that occurs with ageing. Therefore the older someone becomes the closer they are to death, and therefore the lower their muscle mass is likely to be. In addition, the elderly are more likely to become ill than the young, and illness can cause a decrease in muscle mass and this strengthens the positive association between the two factors. That being said, improvements in skeletal muscle mass in the elderly have been shown to improve the quality of life because improvements in body composition bring health benefits including improved flexibility, improved mobility, improved endurance as well as changes to many biochemical parameters. Strategies to improve skeletal muscle and physical strength are therefore of interest to nutritional and health researchers.
High protein diets may have particular benefits at increasing fat free mass in the elderly. For example, in one study researcher administered 22 gram of whey protein, 10.9 grams of essential amino acids including 4 grams of leucine, as well as 2.5 μg of vitamin D (100 IU) to sarcopenic elderly subjects. There was also a physical activity programme. The results showed that the subjects consuming the supplements had 1.7 kg greater increases in fat free mass compared to those performing the physical activity but not taking the supplements. The increase in fat free mass was made up in part by an increase in skeletal muscle, and this was accompanied by improvements in the ability to perform daily tasks. In the supplement group there was also an increase in handgrip strength, a decrease in inflammation and an increase in insulin like growth factor. Taken as a whole these results suggest that protein and vitamin D may cause a significant increase in anabolism, which results in the generation of skeletal muscle mass.
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