Raspberry ketone is a phytochemical that is extracted from raspberry plants. The raspberry ketone chemical name is 4-(4-hydroxyphenyl) butan-2-one.The ketone has a structure similar to capsaicin and synephrine, two compounds with known weight loss effects. Based on this similar structure, studies have investigated the effects of raspberry ketones on weight loss in mice. For example, in one study mice were fed a high diet with 0.5, 1 or 2 % of raspberry ketones for 10 weeks. In this study the raspberry ketones supplement was significantly able to prevent the high fat diet causing elevations in body weight or the deposition of fat in the liver and visceral adipose tissue. In another study, mice were fed a high fat diet for 6 weeks and then fed the same diet with added 1 % raspberry ketones. In this study the raspberry ketones were effective at reducing the body fat accumulation that was caused by the high fat diet in the initial part of the study. The mechanism of action was observed to be due to increased noradrenaline induced lipolysis that increased translocation of hormone sensitive liaise from the cytosol to lipid droplets in epididymal fat cells. These results suggest that high dose raspberry ketones are effective at causing fat loss in mice.
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